MAGNESIUM STEARATE QUALITY INDICATORS TO ESTIMATE ITS LUBRICATION PROPERTIES
نویسندگان
چکیده
Industrial manufacture of palleted medicinal preparations requires the use excipients various purposes among which magnesium stearate is great importance giving lubrication properties to tabletted substance. However, has an unequal lubricating effect despite fact that quality indicators from different manufacturers comply with requirements Pharmacopoeia Monograph. In this work, a comparative analysis Merck KGaA (Germany) and Accent Microcell Pvt. Ltd. (India) was carried out. It found best having smallest particle size predominantly dihydrated form characterized by highest content stearic acid. To identify hydrated forms thermal used making it possible determine dehydration temperatures melting pseudopolymorphic structures endothermic heat effects.
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ژورنال
عنوان ژورنال: Vestnik farmacii
سال: 2021
ISSN: ['2074-9457']
DOI: https://doi.org/10.52540/2074-9457.2021.1.42